ISR News Story
Integrated CMOS Capacitance Sensors for On-Chip Tracking of Cell Proliferation (ISR IP)
ISR intellectual property available to license
Inventors: Somashekar Bangalore Prakash, Pamela Abshire
Researchers at the University of Maryland have developed a novel miniaturized technique in which CMOS capacitance sensors are employed to measure the capacitive coupling between on-chip sensing electrodes and the cellular matrix cultured on them, as a means of tracking cell proliferation. The electrodes are arranged in a planar configuration within the growth chamber and are insulated from the cell environment in order to prevent electrochemical side-effects associated with exposed electrodes. This approach is completely electronic, does not require any sample preparation or biochemical labeling, and allows for online monitoring, experimental automation, and high speed analysis. The sensor chip is designed and fabricated using conventional CMOS technology. There is no required post-processing of the chip, except for a biocompatible packaging step. The integrated capacitance sensing platform offers an easy-to-use, portable and cost-effective solution for tracking cell proliferation in vitro, without requiring extensive laboratory infrastructure.
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June 23, 2007