MOCB Seminar: "Harnessing lipid biology to modify risk for neurodegenerative disease"
Wednesday, November 29, 2023
1103 Bioscience Research Building
Speaker: Priyanka Narayan (National Institute of Diabetes and Digestive and Kidney Diseases)
Title: "Harnessing lipid biology to modify risk for neurodegenerative disease"
Abstract: Alzheimer’s disease and several other neurodegenerative diseases are all characterized by the dysregulation of lipids. Our lab is interested in investigating the role of lipids in mediating risk and resilience to neurodegenerative diseases. We have discovered that neutral lipid homeostasis plays a central role in modulating glial function and that these same lipid pathways are perturbed by isoforms of the neurodegenerative disease-associated factor, APOE. By changing the cellular lipid state, we can modulate disease-relevant cellular functions, providing a potential new avenue for preventative or therapeutic strategies for neurodegenerative diseases.