NG Microsystems Seminar: Shubhra Gangopadhyay, NSF
Tuesday, February 21, 2017
1146 AV Williams Building
Department of Electrical Engineering and Computer Science
University of Missouri
Communications, Circuits, and Sensing Systems(CCSS)
National Science Foundation
Super-resolution Imaging of Nanostructures on Plasmonic Chip
Advanced super-resolution (SR) techniques rely on expensive, sophisticated, and demanding approaches, such as confocal laser scanning microscopy (CLSM), Airyscanning and ground state depletion (GSD) microscopy. On the other hand, the grating-based surface plasmon resonance (SPR) method can overcome the limit of optical resolution through enhancing and propagating electromagnetic field. In this work, silver nanoparticles (NPs) were imaged utilizing inexpensive silver plasmonic grating platform, fabricated by nanoimprint lithography, with different SR approaches including 3D GSD, Airyscanning and blinking localization microscopy with an epi-fluorescence microscope. In addition, the enhanced fluorescence signal from dye molecules provided a unique ability to observe single-molecule (SM) blinking from 10 nM to 1 fM and lower dye concentrations, as well as, to study the localized effects such as temperature fluctuations, nanoparticle mobility, chemical reactions of nanoenergetics on chip, and bio self-assembly in nanoscal.
Dr. Shubhra Gangopadhyay is the LaPierre Endowed Chair Professor in the Department of Electrical Engineering and Computer Science at the University of Missouri. She is the Director of Center of Nanotechnology and Nano/Micro-devices at the College of Engineering. Currently, she is serving as a Program Director at the National Science Foundation. Her areas of expertise include plasmonics for super-resolution imaging of nanostructures and sensing, metal nanoparticle-based memory devices, nanostructured dielectric films for micro/nanoelectronics and sensor applications, chemical and biological sensors using nanotechnology platforms, and nano-energetics for defense and biological applications. She has published over 160 journal papers and graduated 25 Ph.D. and 22 MS students and supervised 31 post-doctoral research associates. She is the Fellow of American Physical Society and the Fellow of the National Academy of Inventors. She co-founded three companies and collaborates with many industries and has been very successful in the development and commercialization of technology.