Faculty Directory

Bentley, William E.

Bentley, William E.

Robert E. Fischell Distinguished Professor
Director, Robert E. Fischell Institute for Biomedical Devices
Fischell Department of Bioengineering
Chemical and Biomolecular Engineering
5102A A. James Clark Hall

EDUCATION

Ph.D., University of Colorado at Boulder, 1989

BACKGROUND

William E. Bentley is the Robert E. Fischell Distinguished Professor of Engineering and founding Chair of the Fischell Department of Bioengineering. He is also appointed to the Department of Chemical and Biomolecular Engineering at the University of Maryland, College Park and the Institute for Bioscience and Biotechnology Research. At Maryland since 1989, Dr. Bentley has focused his research on the development of molecular tools that facilitate the expression of biologically active proteins, having authored over 250 related archival publications. Recent interests are on deciphering and manipulating signal transduction pathways, including those of bacterial communication networks, for altering cell phenotype. To enable discovery, his lab develops new strategies for opening ‘communication’ between devices and biological systems by the creation and facile assembly of biologically functional interfaces. These concepts are emerging as a field of ‘biofabrication’ that exploits biological components and processes for assembly. He has served on advisory committees for the NIH, NSF, DOD, DOE, FDA, USDA, and several state agencies. He has mentored more than 30 PhDs and 15 postdocs, many now in leadership roles within industry (18), federal agencies (4) and academia (22).  He co-founded a protein manufacturing company, Chesapeake PERL, based on insect larvae as mini bioreactors. Dr. Bentley was recipient of the SIM’s Schering-Plough Young Investigator Award, the Charles Thom Award of the SIMB, and the AIChE’s FPB Division Award. He is also a Fellow of the ACS, AAAS, and AIMBE and is an elected member of the American Academy of Microbiology. 

HONORS AND AWARDS

For the complete list, please visit Professor Bentley's web site

  • Charles Thom Award, Society of Industrial Microbiology and Biotechnology (2013)
  • Elected Fellow, American Chemical Society (ACS) (2013)
  • Elected Member, Electorate Nominating Committee, American Association for the Advancement of Science (2013)
  • Meeting Keynote, Upstream Processing, BIOT Division of American Chemical Society’s 245th National Meeting, New Orleans (2013)
  • AIChE Food, Pharmaceutical and Bioengineering Division Award in Chemical Engineering (2012)
  • University System of Maryland (USM) Regents’ Faculty Award for Research/Scholarship/Creative Activity (2011)
  • Robert E. Fischell Distinguished Professor (current)
  • Herbert Rabin Distinguished Professor (former)
  • Fellow, American Academy of Microbiology (AAM) (2007)
  • Fellow, American Association for the Advancement of Science (2001)
  • Fellow, American Institute for Medical and Biological Engineering (2001)
  • Maryland's Outstanding Young Engineer, Maryland Science Center (1998)
  • Washington Academy of Sciences Allen C. Davis Medal (1998)
  • Schering-Plough Young Investigator Award (1996)
  • Dow Outstanding New Faculty Award from the American Society for Engineering Education (1995)
  • Society of Industrial Microbiology Outstanding Achievement in Engineering Sciences Award

PROFESSIONAL MEMBERSHIPS

  • American Academy of Microbiology
  • American Association for the Advancement of Science
  • American Chemical Society
  • American Institute of Chemical Engineers
  • American Institute for Medical and Biological Engineering
  • Biomedical Engineering Society

Biomolecular and metabolic engineering; cell-cell communication; heterologous protein expression; device/bio interfaces.

  • Metabolic and Biomolecular Engineering - Quorum Sensing and in vivo Genetic Manipulation
  • Biofabrication Engineering of Biological Signaling (bBIOS)
  • Bridging the communication gap between biology and electronics through the use of redox molecules
  • Characterization of AI-2 uptake in E. coli quorum sensing circuitry
  • Development of a generic strategy for the covalent assembly of proteins onto patterned surfaces, including sensor surfaces

For more information, please visit Professor Bentley's web site and the Biochip Collaborative

  • For a complete list of publications, please visit Professor Bentley's web site
  • Terrell J.L., Wu H.C., Tsao C.Y., Barber N.B., Servinsky M.D., Payne G.F., and Bentley W.E. (2015) Nano-guided cell networks as conveyors of molecular communication, Nature Communications, doi: 10.1038/ncomms9500.
  • Payne, G.F., Kim, E., Cheng, Y., Wu, H-C., Ghodssi, R., Rubloff, G.W., Raghavan, S.R., Culver, J.N, and W.E. Bentley (2013) Accessing Biology’s Toolbox for the Mesoscale Biofabrication of Soft Matter, Soft Matter, doi:10.1039/c3sm50527h.
  • Bacalocostantis, I., Mane, V.P., Goodley, A.S., Bentley, W.E., Muro, S., and P. Kofinas (2013) Investigating Polymer Thiolation in Gene Delivery, J. Biomaterials Science and Polymer Ed, 24(8):912-926.
  • Betz, J.F., Cheng, Y., Tsao, C.-Y., Zargar, A., Luo, X, Payne, G.F., Bentley, W.E., and G.W. Rubloff (2013) Optically Clear Alginate Hydrogels for Spatially Controlled Cell Entrapment and Culture at Microfluidic Electrode Surfaces. Lab on a Chip, 13(10): 1854-1858.
  • Kim, E., Gordonov, T., Bentley, W. E., and G.F. Payne (2013) Amplified and in situ detection of redox-active metabolite using a biobased redox capacitor, Analytical Chemistry 85, 2102-2108.
  • Kim, E., Gordonov, T., Liu, Y., Bentley, W. E., and G. F. Payne (2013) Reverse engineering to suggest biologically relevant redox activities of phenolic materials, ACS Chemical Biology 8, 716-724.
  • Liba, B. D., Kim, E., Martin, A. N., Liu, Y., Bentley, W. E., and G.F. Payne (2013) Biofabricated film with enzymatic and redox-capacitor functionalities to harvest and store electrons, Biofabrication 5, 015008.
  • Liu, Y., B. Zhang, K. M. Gray, Y. Cheng, E. Kim, G. W. Rubloff, W. E. Bentley, Q. Wang, G. F. Payne (2013) Electrodeposition of a Weak Polyelectrolyte Hydrogel: Remarkable Effects of Salt on Kinetics, Structure and Properties. Soft Matter, 9; 2703-2710.
  • Gupta, A., Terrell, J.L., Fernandes, R., Dowling, M.B., Payne, G.F., Raghavan, S.R., and W.E. Bentley (2013) Encapsulated Fusion Protein Confers “Sense and Respond” Activity to Chitosan-Alginate Capsules to Manipulate Bacterial Quorum Sensing. Biotechnology and Bioengineering, 110, 552-562.
  • Payne, G.F., E. Kim, Y. Cheng, H-C. Wu, R. Ghodssi, G.W. Rubloff, S.R. Raghavan, J.N. Culver, and W.E. Bentley. (2013) Accessing Biology's Toolbox for the Mesoscale Biofabrication of Soft Matter. Soft Matter, 9, 6019-6032.
  • Wu, H.-C., Hebert, C.G., Hung, C.-W., Quan, D.N., Carter, K.K., and W.E. Bentley (2013) Tuning Cell Cycle of Insect Cells for Enhanced Protein Production. Journal of Biotechnology, 10.1016/j.biotec.2013.08.017.
  • Wu, H. C., Tsao, C. Y., Quan, D. N., Cheng, Y., Servinsky, M. D., Carter, K. K., Jee, K. J., Terrell, J. L., Zargar, A., Rubloff, G. W., Payne, G. F., Valdes, J. J., and  W.E. Bentley (2013) Autonomous bacterial localization and gene expression based on nearby cell receptor density, Molecular Systems Biology 9, 636.
  • Bentley, W.E., and G.F. Payne (2013) Nature’s Other Self-Assemblers, Science, 341(6142): 136-137.
  • Carter, K.K., Valdes, J.J., and W.E. Bentley (2012) Pathway Engineering via Quorum Sensing and sRNA Riboregulators – Interconnected Networks and Controllers, Metabolic Engineering, 14(3): 281-288.
  • Terrell, J.L., Gordonov, T., Cheng, Y., Wu, H.C., Sampey, D., Luo, X., Tsao, C.Y., Ghodssi, R., Rubloff, G.W., Payne, G.F., and W.E. Bentley (2012) Integrated Biofabrication for Electro-Addressed In-Film Bioprocessing, Biotechnology Journal, 7(3):428-439.
  • Cheng, Y., Tsao, C.-Y., Wu, H.-C., Luo, X.L., Terrell, J.L., Betz, J., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2012) Electroaddressing Functionalized Polysaccharides as Model Biofilms for Interrogating Cell Signaling, Advanced Functional Materials, 22(3):519-528.
  • Liu, Y., Terrell, J.L., Tsao, C.-Y., Wu, H.C., Jawaji, V., Kim, E., Cheng, Y., Wang, Y.F., Ulijn, R.V., Raghavan, S.R., Rubloff, G.W., Bentley, W.E., and G.F. Payne (2012) Biofabricating Multifunctional Soft Matter with Enzymes and Stimuli-Responsive Materials, Advanced Functional Materials, 22(14):3004-3012.
  • Luo, X.L., Wu, H.C., Tsao, C.-Y., Cheng, Y., Betz, J., Payne, G.F., Rubloff, G.W., and W.E. Bentley (2012) Biofabrication of Stratified Biofilm Mimics for Observation and Control of Bacterial Signaling, Biomaterials, 33(20): 5136-5143.
  • Gamby, S., Roy, V., Guo, M., Smith, J.A.I., Wang, J.X., Stewart, J.E., Wang, X., Bentley, W.E., and H.O. Sintim (2012) Altering the Communication Networks of Multispecies Microbial Systems Using a Diverse Toolbox of AI-2 Analogues, ACS Chemical Biology, 7(6):1023-1030.
  • Kim, E., Liu, Y., Bentley, W.E., and G.F. Payne (2012) Redox Capacitor to Establish Bio-Device Redox-Connectivity, Advanced Functional Materials, 22(7):1409-1416.
  • Gray, K. M., B. D. Liba, Y. Wang, Y. Cheng, G. W. Rubloff, W. E. Bentley, A. Montembault, I. Royaud, L. David, G. F. Payne (2012) Electrodeposition of a Biopolymeric Hydrogel: Potential for One-step Protein Electroaddressing. Biomacromolecules, 13(4), 1181-1189.
  • Gordonov, T., Liba, B., Terrell, J.L., Cheng, Y., Luo, X., Payne, G.F. and W.E. Bentley (2012) Bridging the Bio-electronic Interface with Biofabrication, Journal of Visualized Experiments, doi:10.379/4321.
  • Liu, Y., V. Javvaji, S. R. Raghavan, W. E. Bentley, G. F. Payne (2012) Glucose Oxidase Mediated Gelation: A Simple Test to Detect Glucose in Food Products. Journal of Agricultural and Food Chemistry, 60(36):8963-8967.
  • Cheng, Y., Luo, X.L., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2012) Biofabrication: Programmable Assembly of polysaccharide hydrogels in microfluidics as biocompatible scaffolds. J. Mater. Chem. 22(16), 7659-7666.
  • Kim, Y.W., Sardari, S.E., Meyer, M.T., Iliadis, A.A., Wu, H.C., Bentley, W.E., and R. Ghodssi (2012) An ALD Aluminum Oxide Passivated Surface Acoustic Wave Sensor for Early Biofilm Detection. Sensors and Actuators B 163:136-145.
  • Quan, D., W.E. Bentley (2012) Gene Network Homology in Prokaryotes Using a Similarity Search Approach: Queries of Quorum Sensing Signal Transduction. PLoS Computational Biology. E1002637.
  • Ben-Yoav, H., Dykstra, P.H., Bentley, W.E., and R. Ghodssi. (2012) A Microfluidic-based Electrochemical Biochip for Label-free Diffusion-restricted DNA Hybridization Analysis. Biosensors and Bioelectronics, 38(1):114-120.
  • Roy, V., Meyer, M.T., Smith, J.A., Gamby, S., Sintim, H.O., Ghodssi, R., and W.E. Bentley (2012) AI-2 Analogs and Antibiotics: A Synergistic Approach to Reduce Bacterial Biofilms. Applied Microbiology and Biotechnology, (10.1007/s00253-012-4404-6).
  • Tsao, C.-Y., Quan, D.Q. and W.E. Bentley (2012) Development of the Quorum Sensing Biotechnological Toolbox. Current Opinion in Chemical Engineering, DOI: 10.1016/j.coche.2012.09.008.
  • Liu, Y., J. L. Terrell, C.-Y. Tsao, H.-C. Wu, V. Javvaji, E. Kim, Y. Cheng, Y. Wang, R. V. Ulijn, S. R. Raghavan, G. W. Rubloff, W. E. Bentley, G. F. Payne. (2012) Biofabricating Multi-functional Soft Matter with Enzymes and Stimuli-Responsive Materials. Advanced Functional Materials, doi: 10.1371/journal.pcbi.1002637.
  • Tsao, C.Y., Hooshangi, S., Wu, H.C., Valdes, J.J., and W.E. Bentley (2010) Autonomous Induction of Recombinant Proteins by Minimally Rewiring Native Quorum Sensing Regulon of E. coli, Metabolic Engineering, 12(3):291-297.
  • Terrell, J.L., Gordonov, T., Cheng, Y., Wu, H.C., Sampey, D., Luo, X., Tsao, C.Y., Ghodssi, R., Rubloff, G.W., Payne, G.F., and W.E. Bentley (2011) Integrated Biofabrication for Electro-Addressed In-Film Bioprocessing, Biotechnology Journal, (Epub, PMID 22213675).
  • Carter, K.K., Valdes, J.J., and W.E. Bentley (2011) Pathway Engineering via Quorum Sensing and sRNA Riboregulators – Interconnected Networks and Controllers, Metabolic Engineering, (Epub, PMID22155614).
  • Luo, X.L., Buckhout-White, S., Bentley, W.E., and G.W. Rubloff (2011) Biofabrication of Chitosan-Silver Composite SERS Substrates Enabling Quantification of Adenine by a Spectroscopic Shift, Biofabrication, 3(3):034108.
  • Cheng, Y., Luo, X., Tsao, C.-Y., Wu, H.C., Betz, J., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2011) Biocompatible multi-address 3D Cell Assembly in Microfluidic Devices Using Spatially Programmable Gel Formation, Lab on a Chip, 11(14):2316-2318.
  • Kamaraju, K., Smith, J., Wang, J., Roy, V., Sintim, H.O., Bentley, W.E., and S. Sukharev (2011) Effects on Membrane Lateral Pressure Suggest Permeation Mechanisms for Bacterial Quorum Sensing Molecules, Biochemistry, 50(32):6983-93.
  • Wang, Y., Liu, Y., Cheng, Y., Kim, E., Rubloff, G.W., Bentley, W.E., and G.F. Payne (2011) Coupling Electrodeposition with Layer-by-Layer Assembly to Address Proteins within Microfluidic Channels, Advanced Materials, 23(8):5817-5821
  • Hooshangi, S., and W.E. Bentley (2011) LsrR Quorum Sensing “Switch” is Revealed by a Bottom-up Approach, PLoS Computational Biology, 7(9):e1002172.
  • Dykstra, P.H., Roy, V., Byrd, C., Bentley, W.E., and R. Ghodssi (2011) Microfluidic Electrochemical Sensor Array for Characterizing Protein Interactions with Various Functionalized Surfaces, Analytical Chemistry, 83(15):5920-5927.Dykstra, P.H., Roy, V., Byrd, C., Bentley, W.E., and R. Ghodssi (2011) Microfluidic Electrochemical Sensor Array for Characterizing Protein Interactions with Various Functionalized Surfaces, Analytical Chemistry, 83(15):5920-5927.
  • Roy, V., Adams, B.L., and W.E. Bentley (2011) Developing Next Generation Antimicrobials by Intercepting AI-2 Mediated Quorum Sensing, Enzyme and Microbial Technology, 49(2): 113-123.
  • Liu, Y., Yi, C., Wu, H.C., Kim, E., Ulijn, R.V., Rubloff, G.W., Bentley, W.E., and G.F. Payne (2011) Electroaddressing Agarose Using Fmoc-Phenylalanine as a Temporary Scaffold, Langmuir, 27(12):7380-7384.
  • Liu, Y., Kim, E., Ulijn, R.V., Bentley, W.E., and G.F. Payne (2011) Reversible Electroaddressing of Self-assembling Amino-Acid Conjugates, Advanced Functional Materials, 21(9):1575-1580.
  • Meyer, M.T., Roy, V., Bentley, W.E., and R. Ghodssi (2011) Development and Validation of a Microfluidic Reactor for Biofilm Monitoring via Optical Methods, Journal of Micromechanics and Microengineering, 21(5) (#054023).
  • Tsao, C.Y., Wang, L., Hashimoto, Y., Yi, H., March, J.C., Delisa, M.P., Wood, T.K., Valdes, J.J., and W.E. Bentley (2011) LuxS Co-expression Enhances Yield of Recombinant Proteins in E. coli in part through Post-transciptional control of GroEL. Applied and Environmental Microbiology, 77(6):2141-2152.
  • Liu, Y., Shi, X.W., Kim, E., Robinson, L.M., Nye, C.K., Ghodssi, R., Rubloff, G.W., Bentley, W.E., and G.F. Payne (2011) Chitosan to Electroaddress Biological Components in Lab-on-a-Chip Devices, Carbohydrate Polymers, 84(2):704-708.
  • Wu, L.Q., Bentley, W.E., and G.F. Payne (2011) Biofabrication with biopolymers and enzymes: Potential for constructing scaffolds from soft matter, International Journal of Artificial Organs, (E-Pub).
  • Kim, E., Liu, Y., Baker, C.J., Owens, R., Xiao, S., Bentley, W.E., and G.F. Payne (2011) Redox-cycling and H(2)O(2) Generation by Fabricated Catecholic Films in the Absence of Enzymes, Biomacromolecules, 12(4):880-888.
  • Gray, K.M., Kim, E., Wu. L-Q., Liu, Y., Bentley, W.E., and G.F. Payne (2011) Biomimetic Fabrication of Information-Rich Phenolic-Chitosan Films, Soft Matter, 7(20):9601-9615.
  • Cheng, Y., Luo, X., Betz, J., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2011) Mechanism of Anodic Electrodeposition of Calcium Alginate, Soft Matter, 7(12), 5677-5684.
  • Fernandes, R., Roy, V., Wu, H.C., and W.E. Bentley (2010) Engineered biological nanofactories trigger quorum sensing response in targeted bacteria, Nature Nanotechnology, 5(3)213-217.
  • Fernandes R., Luo, X., Tsao, C.-Y., Payne, G.F., Ghodssi, R., Rubloff, G.W., and W.E. Bentley (2010) Biological Nanofactories Facilitate Spatially Selective Capture and Manipulation of Quorum-Sensing Bacteria in a BioMEMS Device, Lab on a Chip, 10(9):1128-1134.
  • Roy, V., Fernandes, R., Tsao, C.Y., and W.E. Bentley (2010) Cross Species Quorum Quenching Using A Native AI-2 Processing Enzyme, ACS Chemical Biology, 5(2):223-232.
  • Koev, S.T., Bentley, W.E., Ghodssi, R (2010) Interferometric readout of multiple cantilever sensors in liquid samples, Sensors and Actuators B–Chemical, 146(1):245-252.
  • Yang, X.H., Kim, E., Liu, T., Shi, X.W., Rubloff, G.W., Ghodssi, R., Bentley, W.E., and G.F. Payne (2010) In-film Bioprocessing and Immunoanalysis with Electroaddressable Stimuli-Responsive Polysaccharides, Advanced Functional Materials, 20(10):1645-1652.
  • Liu, Y., Kim, E., Ghodssi, R., Rubloff, G.W., Culver, J.N., Bentley, W.E., and G.F. Payne (2010) Biofabrication to Build the Biology-Device Interface, Biofabrication, 2(2):220.
  • Kim, E., Liu, Y., Shi, X.W., Yang, X., Bentley, W.E., and G.F. Payne (2010) Biomimetic Approach to Confer Redox Activity to Thin Chitosan Films, Advanced Functional Materials, (in press).
  • Roy, V., Smith, J.A., Wang, J., Stewart, J.E., Bentley, W.E., and H.O. Sintim (2010) Synthetic Analogs Tailor AI-2 Signaling Across Bacterial Species, Journal of the American Chemical Society, (online).
  • Bauer, R.I., Luo, X., and W.E. Bentley (2010) Chips & Tips: Customizable PDMS Chamber for Cell Imaging, Lab on a Chip, (in press).
  • Hebert, C., Gupta, A., Tsao, C-Y., Valdes, J.J., and W.E. Bentley (2010) Biological Nanofactories target and Activate Epithelial Cell Surfaces for Modulating Bacterial Quroum Sensing and Interspecies Signaling, ACS Nano, (e pub).
  • Lee, J., Bansal, T., Jayaraman, A., Bentley, W.E., and T.K. Wood (2007) Enterohemorrhagic Escherichia coli Biofilms are Inhibited by 7-Hydroxyindole and Stimulated by Isatin, Applied and Environmental Microbiology.
  • Yung, C.W., Tullman, J.A., Payne, G.F., Bentley, W.E., and T.A. Barbari (2007) Transglutaminase Crosslinked Gelatin as a Tissue Engineering Scaffold, Journal of Biomedical Materials Research A, (Epub ahead of print).
  • Li, J., Attila, C., Wang, L., Wood, T.K., Valdes, J.J., and W.E. Bentley (2007) Quorum Sensing in E. coli is Signaled by AI-2/LsrR: Effects on sRNA and Biofilm Architecture, Journal of Bacteriology, 73:4100-4109.
  • Fernandes, R., Tsao, C.Y., Hashimoto, Y., Wang, L., Wood, T.K., Payne, G.F., and W.E. Bentley (2007) Magnetic Nanofactories: Localized Synthesis and Delivery of Quorum-Sensing Signaling Molecule Autoinducer-2 to Bacterial Cell Surfaces, Metabolic Engineering, 9:228-239.
  • Small, D.A., Chang, W., Bentley, W.E., and F. Toghrol (2007) Toxicogenomic Analysis of Sodium Hypochlorite Antimicrobial Mechanisms in Pseudomonas aeruginosa, Applied Microbiology and Biotechnology, 74:176-185.
  • Kim, E.J., Kramer, S.F., Hebert, C.G., Valdes, J.J., and W.E. Bentley (2007) Metabolic Engineering of the Baculovirus-Expression System via Inverse "Shotgun" Genomic Analysis & RNA Interference (dsRNA) Increases Product Yield and Cell Longevity, Biotechnology and Bioengineering, 98:645-654.
  • March, J.C., and W.E. Bentley (2007) RNAi-based Tuning of Cell Cycling in Drosophila S2 cells- effects on Recombinant Protein Yield, Applied Microbiology and Biotechnology, 73: 1128-1135.
  • Koev, S.T., Powers, M. A. Powers, Yi, H.M., Wu, L-Q., Bentley, W.E., Rubloff, G.W., Payne, G.F., and R. Ghodssi, (2007) Mechano-transduction of DNA Hybridization and Dopamine Oxidation through Electrodeposited Chitosan Network, Lab on a Chip, 7:103-111.
  • Small, D.A, Chang, W., Toghrol, F., and W.E. Bentley (2007) Comparative Global Transcription Analysis of Sodium Hypochlorite, Peracetic Acid, and Hydrogen Peroxide on Pseudomonas aeruginosa, Applied Microbiology and Biotechnology, 76:1093-1105.
  • O’Connell, K.P., Kovaleva, E., Campbell, J.H., Anderson, P.E., Brown, S.G., Davis, D.C., Valdes, J.J., Welch, R.W., Bentley, W.E. and N.A. van Beek (2007) Production of a Recombinant Antibody Fragment in Whole Insect Larvae, Molecular Biotechnology, 36:44-51.
  • Hung, C-W., Holoman, T.R.P., Kofinas, P., and W.E. Bentley (2007) Towards Oriented Assembly of Proteins onto Magnetic Nanoparticles, Biochemical Engineering Journal.
  • Saini, S.S., Stanford, C., Lee, S.M., Park, J., DeShong, P., Bentley, W.E., and M. Dagenais (2007) Monolayer Detection of Biochemical Agents Using Etched-Core Fiber Bragg Grating Sensors, IEEE Photonics Technology Letters, 19:1341-1343.
  • Lewandowski, A.T., Yi, H., Luo, X., Payne, G.F., Ghodssi, R., Rubloff, G.W., and W.E. Bentley (2007) Protein Assembly onto Patterned Microfabricated Devices through Enzymatic Activation of Fusion Pro-tag. Biotechnology and Bioengineering.
  • March, J.C., and W.E. Bentley (2007) Methods for gene silencing with RNAi, Methods in Molecular Biology, 388:424-434.
  • Hu, Y.C., and W.E. Bentley (2007) Alternative Bioreactor Strategy for Probing Infection and Production, Methods in Molecular Biology, 388:419-426.
  • Cha, H.J., and W.E. Bentley (2007) Monitoring and Visualization of Baculovirus Infection Using Green Fluorescent Protein Strategy, Methods in Molecular Biology, 388:407-418.
  • Lewandowski, A.T., Small, D.A., Chen, T., Payne, G.F., and W.E. Bentley (2006) Tyrosine-based "activatable pro-tag": enzyme-catalyzed protein capture and release, Biotechnology and Bioengineering, 93:1207-1215.
  • Chang, W., Small, D.A., Toghrol, F., and W.E. Bentley (2006) Global Transcriptome Analysis of Staphylococcus aureus Response to Hydrogen Peroxide, Journal of Bacteriology, 188:1648-1659.
  • Gonzalez Barrios, A.F., Zuo R., Hashimoto, Y., Yang, L., Bentley W.E., and T.K. Wood (2006) Autoinducer 2 Controls Biofilm Formation in Escherichia coli Through a Novel Motility Quorum-sensing Regulator (MqsR, B3022), Journal of Bacteriology, 188:205-316.
  • Bleckwenn, N. A. and Bentley, W.E. (2006) Systems and Technology Involving Bacteria, In CRC BME Handbook: Tissue Engineering and Artificial Organs (JD Bronzino, ed.) CRC Press, Boca Raton, FL, 2.1-2.10.
  • Yung, C., Barbari, T.A., and W.E. Bentley (2006) Integrated Non-Invasive System for Quantifying Secreted Human Therapeutic hIL2, Biotechnology and Bioengineering.
  • Yang, L., Portugal, F.H., and W.E. Bentley (2006) Conditioned Medium from Listeria innocua Stimulate Emergence from a Resting State not in Response to Quorum Sensing Autoinducer AI-2, Biotechnology Progress, 22:387-393.
  • March, J.C., and W.E. Bentley (2006) Engineering Eukaryotic Signal Transduction with RNAi: Enhancing Drosophila S2 Cell Growth and Recombinant Protein Synthesis via Silencing of TSC1. Biotechnology and Bioengineering.
  • Park, J.J., Valentine, T.M., Yi, H., Payne, G.F., Bentley, W.E., Ghodssi, R., and Gary W. Rubloff (2006) In situ Biomolecule Assembly in Completely Packaged Microfluidic Devices, Lab on a Chip.
  • Yung, C.W., Barbari, T.A., and W.E. Bentley (2006) Counteracting Apoptosis and Necrosis with Hypoxia Responsive Expression of Bcl-2D, Metabolic Engineering.
  • Cresce, A.V., Silverstein, J.S., Bentley, W.E., and P. Kofinas (2006) Nanopatterning of Recombinant Proteins using Block Copolymer Templates, Macromolecules, 39, 5826-5829.
  • Dalal, N.G., Cha, H.J., Kramer, S.F., Kostov, Y., Rao, G. and W.E. Bentley (2006) Rapid Non-invasive Monitoring of Baculovirus Infection for Insect Larvae Using Green Fluorescent Protein Reporter Under Early-to-Late Promoter and a GFP-Specific Optical Probe, Process Biochemistry, 41:947-950.
  • Li, J., Wang, L., Hashimoto, Y., Tsao, C-Y., Wood, T.K., Valdes, J.J., Zafiriou, E., and W.E. Bentley (2006) Stochastic Model of E. coli AI-2 Quorum Signal Circuit Reveals Alternative Synthesis Pathways, Nature Molecular Systems Biology.
  • Wang, L., Hashimoto, Y., Tsao, C.-Y., Valdes, J.J., and W.E. Bentley (2005) cAMP and cAMP Receptor Protein (CRP) Influence Both  Synthesis and Uptake of Extracellular Autoinducer-2 in Escherichia coli, Journal of Bacteriology, 187:2066-76.
  • Yi, H., Wu, L.Q., Rubloff, G.W., Ghodssi, R., Payne, G.F., and Bentley, W.E., (2005) Signal-Directed Sequential Assembly of Biomolecules on Patterned Surfaces. Langmuir, 2:2104-2107.
  • Tao, Y., Bentley, W.E., and T.K. Wood, (2005) Regiospecific Oxidation of Naphthalene and Fluorene by Toluene Monooxygenase and Engineered Toluene 4-Monooxygenase of Pseudomonas mendocina KR1, Biotechnology and Bioengineering, 90:85-94.
  • Cha, H.J., Shin, H.S., Lim, H.J., Cho, H.S., Dalal, N.N., Pham, M.Q., and W.E. Bentley (2005) Comparative Production of Human Interleukin-2 Fused with Green Fluorescent Protein in Several Recombinant Expression Systems, Biochemical Engineering Journal, 24:225-233.
  • Lu C.H., Albano C.R., Bentley W.E., and G. Rao (2005) Quantitative and kinetic study of oxidative stress Regulons using green fluorescent protein, Biotechnology and Bioengineering, 89: 574-587.
  • Bleckwenn, N. A., Bentley, W. E., Shiloach, J., (2005) Vaccinia Virus-Based Expression of gp120 and EGFP: Survey of Mammalian Host Cell Lines, Biotechnology Progress, 21:186-191.
  • Bleckwenn, N. A., Bentley, W. E., Shiloach, J., (2005) Evaluation of Production Parameters with the Vaccinia Virus Expression System Using Microcarrier Attached HeLa Cells, Biotechnology Progress, 21:554-561.
  • Bleckwenn, N. A., Bentley, W. E., Shiloach, J., (2005) Production of Recombinant Protein Using the HeLa S3-Vaccinia Virus Expression System: Bioreactor Perfusion and Effects of Post-Infection Temperature, Journal of Bioscience, Biotechnology and Biochemistry, 69:1065-1072.
  • Bleckwenn, N. A., Golding, H., Bentley, W. E., Shiloach, J., (2005) Production of Recombinant Proteins by Vaccinia Virus in a Microcarrier Based Mammalian Cell Perfusion Bioreactor, Biotechnology and Bioengineering, 90:663-674.
  • Tao, Y., Bentley, W.E., and Wood, T.K. (2005) Phenol and 2-Naphthol Production by Toluene 4-Monooxygenases Using an Aqueous/Dioctyl Phthalate system, Applied Microbiology & Biotechnology, 68:614-621. 
  • Dalal, N.G., Bentley, W.E., and H.J. Cha (2005) Facile Monitoring of Baculovirus Infection for Foreign Protein Expression under Very Late Polyhedrin Promoter using Green Fluorescent Protein Reporter under Early-to-Late Promoter, Biochemical Engineering Journal, 24:27-30.
  • Cha, H.J., Dalal, N.G., and Bentley, W.E. (2005) Secretion of Human Interleukin-2 Fused with Green Fluorescent Protein in Recombinant Pichia pastoris, Applied Biochemistry and Biotechnology, 126:1-11.
  • Powers, M.A., S. T. Koev, A. Schleunitz, H. Yi, V. Hodzic, W. E. Bentley, G. F. Payne, G. W. Rubloff, and R. Ghodssi (2005) Integrated Optical Sensing of Biofunctionalized Sites in BioMEMS, Lab on a Chip, 5:583-586.
  • Chryssis, A.N., Saini, S.S., Lee, S.M., Yi, H.M., Bentley, W.E., and M. Dagenais (2005) Detecting Hybridization of DNA by Highly Selective Evanescent Field Etched Core Fiber Bragg Grating Sensors, IEEE Journal of Selected Topics in Quantum Electronics, 11:864-872.
  • Chang, W., Small, D.A. Toghrol, F., and W.E. Bentley (2005) Microarray Analysis of Toxicogenomic Effects of Peracetic Acid on Pseudomonas aeruginosa, Environmental Science & Technology, 39:5893-5899.
  • Chang, W., Small, D.A., Toghrol, F., and W.E. Bentley (2005) Microarray Analysis of Pseudomonas aeruginosa Reveals Induction of Pyocin Genes in Response to Hydrogen Peroxide, BMC Genomics, 6.115-129.
  • Yi, H., Nisar, S., Lee, S.Y., Powers, M.A., Bentley, W.E., Payne, GF, Ghodssi, R., Rubloff, G.W., Harris, M.T., Culver, J.N. (2005) Patterned Assembly of Genetically Modified Viral Nanotemplates via Nucleic Acid Hybridization, Nano Letters, 5:1031-1936.
  • Wang, L., Li, J., March, J.C., Valdes, J.J., and W.E. Bentley (2005), luxS-Dependent Gene Regulation in Escherichia coli K-12 Revealed by Genomic Expression Profiling, Journal of Bacteriology, 187:8350-8360.
  • Yi, H., Wu, L.Q., Bentley, W.E., Ghodssi, R., Rubloff, G.W., Culver, J.N., Payne, G.F., (2005) Biofabrication with Chitosan, Biomacromolecules, 6:2881-2894.

NSF Awards $1M Grant to UMD Researchers

The interdisciplinary project will explore the molecular connection between the gut and the nervous system.

Ghodssi Receives Senior Faculty Outstanding Research Award

The award recognizes exceptionally influential research accomplishments by Clark School faculty.

Biofilm treatment device receives TEDCO MII funding; paper published in IEEE TBME

In latest development, the researchers have miniaturized the platform and are able to control it through wireless signals.

NSF grant for Ghodssi, Bentley furthers research of flexible devices to combat biofilms

The researchers will combine applied microbiology with engineering disciplines to explore the complex interactions between flexible sensors, bacterial biofilms, and bioelectric treatment.

‘Smart Marbles’ hold promise for better outcomes from bioreactors

The marbles, or 'bPods,' will contain microsystems that can “eavesdrop on biology” during fermentation, cell or culture-growing processes.

Bridging the Gap between Microelectronics, Biological Systems

UMD researchers receive $1.5 M NSF grant to develop first-of-kind bioelectronics.

Three ISR faculty receive UMD Brain and Behavior Initiative seed grants

Projects featuring Fritz, Babadi and Ghodssi are among seven chosen for FY18 funding.

UMD Researchers Addressing Urinary Tract Infections by Developing Device for Detection and Treatment of Bacterial Biofilms in Catheters

Invention of the Year nominee presents new technology to detect and treat the source of catheter-associated UTIs in hospitalized patients

New microsystems detect, treat bacterial biofilms that cause post-operative infections

'Flexible impedance sensor' can fit inside urinary catheters, monitor and treat biofilms.

Research Review: Combating biofilms with microsystem devices

New microsystems detect, treat bacterial biofilms—the source of many post-operative infections; latest device can sense and treat biofilm inside urinary catheters.

Ghodssi, Bentley receive NSF EAGER grant to develop ingestible capsules for medical diagnosis

"Gut-Nav" capsules will be designed to detect problems in the gastro-intestinal tract, including pancreatic cancer and inflammatory bowel disease screening.

UMD Researchers Make Strides in Schizophrenia Diagnosis Research

Blood test could help doctors more quickly diagnose schizophrenia and other disorders.

Artificial cells that can pass the 'Turing Test'

University of Mryland and Trento researchers have developed artificial cells that can chemically communicate with bacteria.

Four Clark School Professors Named Distinguished University Professor

In 2016, four of the 10 Distinguished University Professors named by the University of Maryland are Clark School professors.

Maryland inventors issued US Patent for compounds that fight biofilms

The compounds enhance the effectiveness of conventional antibiotics and inhibit the formation and persistence of biofilms.

University of Maryland Breaks Ground for A. James Clark Hall

New building to serve as hub for human health innovation in the state of Maryland

UMD Researchers Bridge Gap between Microelectronics, Biological Systems

“Electronic modulation of biochemical signal generation” published in Nature Nanotechnology

International research partnership leads to major publication on controlling living cells with artificial cells

Research could lead to medical therapies carried out by nonliving, artificial cells.

University of Maryland Baltimore & College Park Campuses To Offer Joint M.D./Ph.D. in Medicine and Bioengineering

Program will promote human health through engineering principles and medical science.

Young Wook Kim receives best poster presentation award

The ECE Ph.D. candidate won the award at the Bioscience and Engineering Symposium of the NIH Korean Scientists Association.

Shapiro, Yu Win 2013 BioE Teaching, Graduate Research Awards

Honors presented at annual "Welcome Back" seminar.

UMD-Trento Partnership yields first graduate student exchange

The exchange is part of the "Control of Living Cells Through Communication with Artificial Cells" collaboration.

Rubloff Co-Authors Major DoE Report on Emerging Energy Technologies

Publication focuses on opportunities in mesoscale science.

New Microfluidic Device Could Speed Drug Evaluation

Meyer wins Bioscience Day Poster division for work on device capable of separating, testing distinct areas of same biofilm.

Collaborative international projects funded in solar power, cell-based systems, and ultra-low power systems

Research is part of agreement between Autonomous Province of Trento, Italy, and University of Maryland.

Preventing Costly, Life-Threatening Catheter Infections

Deutsch Foundation-sponsored Clark School research offers multi-pronged attack on major medical problem.

Bacteria Programmed to Re-Create UMD Logo

Feat part of larger body of Clark School research into preventing infections.

Canon, Clark School Launch New Collaboration

Joint team to develop automated machine designed to expedite the diagnosis of infectious diseases.

International partnership agreement being finalized

International relationship will include research and education components.

Rubloff Group Research Selected for Highlights in Chemical Technology.

Paper covers advances in lab-on-a-chip technology.

Stephan Koev wins MEMS Alliance best poster award

Poster highlights research on optical microcantilever sensors for liquid samples.

Vorontsov, Koev, Wei and McKinney win at ISR awards ceremony

Quartet honored for outstanding contributions in 2007–2008.

Ghodssi Named Herbert Rabin Distinguished Professor

Dr. Reza Ghodssi is recognized for sustained and influential scientific and scholarly work.

New Advance in Biochip Research

Microfactories for drug research are one step closer to reality.

Ghodssi, Rubloff part of $2 million NSF grant

Cellular and biomolecular engineering research to focus on biofunctionalized devices.

Thermo-Bio-Lithography (ISR IP)

This IP is available to license.

$1 Million For Nano-Bio Initiative

Deutsch Foudation will fund Clark School bioengineering research on the nanoscale.